The region of Trasierra-Tierras de Granadilla is located in the North-Central sector of the province of Cáceres and delimits the North with the province of Salamanca and the Ambroz Valley, to the west with the Comarca de Las Hurdes and Sierra de Gata, to the south with the city of Plasencia and to the east with the Valle del Jerte.
Territorially we find two very different areas: the Central and Southern plains that encompass most of the territory and the mountain areas of East and North. These orographic contrasts also imply significant altimetric differences and consequently of vegetation, occupation of the space and its use. Giving rise to a well-differentiated landscape between the mountains and the foothills, the plains and the lowlands of the Rivers Ambroz and Alagon.
It is crossed by two important rivers: the Alagon and its tributary the Ambroz, the latter has associated a series of irrigated in La Granja and Zarza de Granadilla.